Dialysis and Hemodialysis Research and News | December 2009
Optimal Medical Therapy With or Without Percutaneous Coronary Intervention for Patients With Stable Coronary Artery Disease and Chronic Kidney Disease
American Journal Cardiology
15 December 2009 (Vol. 104, Issue 12)
This study compare OMT (Optimal Medical Therapy) with Percutaneous Coronary Intervention (PCI) in patients with Chronic Kidney Disease (CKD). PCI is the use of stents to treat obstructed blood vessels in patients with angina or coronary atherosclerosis. Patients with kidney disease also have a high rate of heart disease, which makes sense since the same predisposing conditions especially of hypertension and diabetes can cause both heart disease and kidney disease.
Mutations in the formin gene INF2 cause focal segmental glomerulosclerosis.
Elizabeth Brown, et all Nature Genetics December 2009
A gene causing a form of childhood kidney failure has been discovered and reported in the online version of Nature's Genetics. This gene, located on chromosome 14, was found to be correlated with autosomal dominant FSGS, or focal segmental glomeruloscerosis, a type of kidney disease that leads to loss of protein through the kidney (proteinuria) and eventual kidney failure in children and young adults affected by FSGS.
Body Builders and Kidney Damage
Published: December 9, 2009 New York Times
Steroid usage by body builders may be associated with a risk of severe and potentially life threatening kidney disease. This article examines the lives of professionaal body builders, some of whom went on to experience kidney failure.Good
Chronic Kidney Disease (CKD) associated with poorer breakdown of a lipids.
Kidney disease and heart disease sometimes go together. This study looked at a lipid (fat) molecule and found slower breakdown of an important lipid molecule in kidney disease patients. This slow breakdown may be one clue to the higher rate of heart disease in CKD patients.
FDA panel recommended approval Everolimus in kidney transplantation patients.
The FDA panel backed approval of the Novartis brand name drug Afinitor to help prevent kidney rejection. Everolimus (Afinitor) would be an addition to other drugs used to prevent kidney transplant rejection and would require special monitoring for side effects.
New Feature from Hemodialysis.com: Hemodialysis or Chronic Kidney Disease Abstract of the Week
Association of Cumulatively Low or High Serum Calcium Levels with Mortality in Long-Term Hemodialysis Patients.
Am J Nephrol. 2010 Sep 3;32(5):403-413.
Miller JE, Kovesdy CP, Norris KC, Mehrotra R, Nissenson AR, Kopple JD, Kalantar-Zadeh K.
Harold Simmons Center for Kidney Disease Research and Epidemiology,Torrance, Calif., USA.
Abstract
Background: The outcome-predictability of baseline and instantaneously changing serum calcium in hemodialysis patients has been examined. We investigated the mortality-predictability of time-averaged calcium values to reflect the 'cumulative' effect of calcium burden over time. Methods: We employed a Cox model using up-to-5-year (7/2001-6/2006) time-averaged values to examine the mortality-predictability of cumulative serum calcium levels in 107,200 hemodialysis patients prior to the use of calcimimetics, but during the time where other calcium-lowering interventions, including lower dialysate calcium, were employed.
Results: Both low (<9.0 mg/dl) and high (>10.0 mg/dl) calcium levels were associated with increased mortality (reference: 9.0 to <9.5 mg/dl). Whereas mortality of hypercalcemia was consistent, hypocalcemia mortality was most prominent with higher serum phosphorus (>3.5 mg/dl) and PTH levels (>150 pg/ml).
Higher paricalcitol doses shifted the calcium range associated with the greatest survival to the right, i.e. from 9.0 to <9.5 to 9.5 to <10.0 mg/dl. African-Americans exhibited the highest death hazard ratio of hypocalcemia <8.5 mg/dl, being 1.35 (95% CI: 1.22-1.49). Both a rise and drop in serum calcium over 6 months were associated with increased mortality compared to the stable group.
Conclusions: Whereas in hemodialysis patients cumulatively high or low calcium levels are associated with higher death risk, subtle but meaningful interactions with phosphorus, PTH, paricalcitol dose and race exist.
Hemodialysis | Kidney Disease | Dialysis Resources and Educational Materials
100 Q&A About Kidney Disease and Hypertension
Raymond R. Townsend, MD
High blood pressure is one of the leading causes of kidney failure. Each year, high blood pressure causes more than 25,000 new cases of kidney failure in the United States. 100 Questions & Answers About Kidney Disease and Hypertension offers authoritative, up-to-date, practical answers about kidney disease, end-stage renal disease, transplants, and dialysis. The book is an invaluable resource for anyone coping with the physical and emotional turmoil of this condition.
Handbook of Dialysis Therapy
Here's an in-depth, quick-reference, problem-solving resource for those involved in the care of dialysis patients. More than 120 world-class authorities discuss dialysis techniques, mechanical considerations, and complications related to various diseases for both pediatric and adult patients. Selected annotated references and excellent cross-referencing between chapters help you find answers fast, and more than 100 photos, drawings, charts, and tables, mostly in color, clarify complex topics. Providing practical, immediately useful guidelines that can be applied directly to patient care, this book is a "must-have" for all dialysis caregivers.
Certified Hemodialysis Technologist/Technician Exam Secrets Study Guide: CHT Test Review for the Certified Hemodialysis Technologist/Technician Exam
Certified Hemodialysis Technologist/Technician Exam Secrets helps you ace the Certified Hemodialysis Technologist/Technician Exam, without weeks and months of endless studying. Our comprehensive Certified Hemodialysis Technologist/Technician Exam Secrets study guide is written by our exam experts.....
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