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  hemodialysis News and hemodialysis Current Topics
NEWS: Hemodialysis - Dialysis - ESRD - CKD News & Research Interviews
Depressive symptoms associate with high mortality risk & dialysis withdrawal in incident hemodialysis patients:
Dr. Lacson
Nephrology Dialysis Transplant
Global Trends in Rates of Peritoneal Dialysis: Dr. Jain JASN
Structural Equation Modeling Highlights the Potential of Kim-1 as CKD Biomarker: Dr. Gardiner Am J Nephrology
Protective effects of PPARγ agonist in acute nephrotic syndrome: Dr. Fogo Nephrology Dialysis Transplant
A Computerized Treatment Algorithm Trial to Optimize Mineral Metabolism in ESRD: Dr. Spiegel CJASN
Development/Validation of Expedited 10g Protein Counter for Dietary Protein Intake : SL Lim J.Renal Nutrition
IL-6-independent risk factor for ESAs resistance in hemodialysis pts without iron deficiency: Dr. Kim Hemodialysis Int'l
Troponin I & Postoperative Myocardial Infarction after Renal Transplantation : Dr. Shroff Amer J Nephrology
Longitudinal Progression Trajectory of GFR in CKD: Dr. Li : AJ Kidney Disease

Top 7 Fitness Exercise Tips for Kidney Patients

Regular exercise improves muscle function, helps control blood pressure, lowers cholesterol and increases quality of sleep.

Despite the multiple benefits, many chronic kidney disease patients do not exercise enough due to concerns regarding what type of exercise they can do, how often they should exercise and how to create a fitness schedule.

This month, the National Kidney Foundation answers 7 common fitness questions from CKD patients.

  1. What types of exercise can I do?
    Choose continuous activity such as walking, swimming, bicycling (indoors or out), skiing, aerobic dancing or any other activities in which you need to move large muscle groups continuously.

Low-level strengthening exercises may also be beneficial as part of your program. Design your program to use low weights and high repetitions, and avoid heavy lifting.
One simple way to exercise and help many others with CKD is to join a local Kidney Walk

  1. How often and for how long should I exercise for?
    Exercise at least three days a week. These should be non-consecutive days, for example, Monday, Wednesday and Friday. Three days a week is the minimum requirement to achieve the benefits of your exercise. Work toward 30-minute sessions. Remember to build up gradually to this level.

  1. Can I take part in vigorous physical activity?
    Yes. In the past, it was thought that people with kidney disease would not be able to join in vigorous activity. We know now that patients who decide to follow an exercise program are stronger and have more energy.

  1. How hard should I work while exercising?
    This is the most difficult to talk about without knowing your own exercise capacity. Usually, the following ideas are helpful:

    • Your breathing should not be so hard that you cannot talk with someone exercising with you. Try to get an exercise partner such as a family member or a friend.

    • You should feel completely normal within one hour after exercising. If not, slow down next time.

    • You should not feel so much muscle soreness that it keeps you from exercising the next session.

The intensity should be a "comfortable push" level. Start out slowly each session to warm up, then pick up your pace, then slow down again when you are about to finish. The most important thing is to start slowly and progress gradually, allowing your body to adapt to the increased levels of activity.

  1. When should I exercise?
    Try to schedule your exercise into your normal day. Here are some ideas about when to exercise:

    • Wait one hour after a large meal

    • Avoid the very hot times of the day

    • Morning or evening seems to be the best time for exercising

    • Do not exercise less than an hour before bedtime

  1. When should I stop exercising?
    You should stop exercising if you feel any of the following:

    • Very tired

    • Shortness of breath

    • Chest pain

    • Irregular or rapid heart beats

    • Sick to your stomach

    • Leg cramps

    • Dizzy or light-headed

  1. Are there any times when I should not exercise?
    Yes. You should not exercise without talking with your doctor if any of the following occurs:

    • You have a fever

    • You have changed your dialysis schedule

    • You have changed your medicine schedule

    • Your physical condition has changed

    • You have eaten too much

    • The weather is very hot and humid

    • You have joint or bone problems that become worse with exercise

If you stop exercising for any of these reasons, speak to your doctor before beginning again.

Author Interview: Dr. Mattew Abramowitz

Association of serum bicarbonate levels with gait speed and quadriceps strength in older adults.
Abramowitz MK, Hostetter TH, Melamed ML.


Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY.
Am J Kidney Dis. 2011 Jul;58(1):29-38.

Author Interview Dr. Neil Smart Ph.D
Exercise Training in Hemodialysis Patients: A Systematic Review and Meta-Analysis
Neil Smart Ph.D. Michael Steele Ph.D.

Nephrology Accepted Article DOI: 10.1111/j.1440-1797.2011.01471.x
Dept. Exercise Science, University New England, NSW 2350, Australia
Faculty of Health Science and Medicine, Bond University, QLD 4229 Australia

Author Interview: Dr. Dorien M. Zelle,
Low Physical Activity and Risk of Cardiovascular and All-Cause Mortality in Renal Transplant Recipients


Dorien M. Zelle, Eva Corpeleijn,  Ronald P. Stolk, Mathieu H.G. de Greef, Rijk O.B. Gans, Jaap J. Homan van der Heide, Gerjan Navis, and Stephan J.L. Bakker

Dr. Dorien M. Zelle, Department of Nephrology, University Medical Center Groningen, Sector A, PO Box 30001, 9700 RB, Groningen, The Netherlands
CJASN April 2011 6):(4)898-905, doi:10.2215/CJN.03340410

Author Interview: Denise Mafra Influence of Inflammation on Total Energy Expenditure in Hemodialysis Patients.

Mafra D, Deleaval P, Teta D, Cleaud C, Arkouche W, Jolivot A, Fouque D.
J Ren Nutr. 2011 Jan 14.

Fresenius Medical Care Urges People with Kidney Failure to Get Fit for Better Health

During National Kidney Month, Company Suggests Regular Exercise to Help People Manage Kidney Disease

WALTHAM, Mass. – March 16, 2011 Research has shown that regular exercise can be helpful in managing chronic kidney disease (CKD), and can limit its harmful effects on the body. During National Kidney Month this March, Fresenius Medical Care North America (FMCNA), the nation’s leading network of dialysis facilities, is urging the growing population of people on dialysis to exercise frequently, which can improve their day-to-day energy and quality of life.

Patients who engage in little physical activity face increased risks of dying prematurely 

Washington, DC (February 25, 2011) — Low physical activity increases kidney
transplant patients’ likelihood of dying early, according to a study appearing in an
upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN).
The results suggest that patients need to exercise to fend off an early death.

Association of Self-reported Physical Activity With Laboratory Markers of Nutrition and Inflammation: The Comprehensive Dialysis Study.

J Ren Nutr. 2011 Jan 14.

Anand S,  Chertow GM, Johansen KL, Grimes B, Tamura MK, Dalrymple LS, Kaysen GA.
Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Palo Alto, California

FLEXING THEIR MUSCLES HELPS KIDNEY DISEASE PATIENTS LIVE LONGER

Patients with Large Upper Arm Muscles Gain Improved Health and Survival 

Washington, DC (October 8, 2010) — Kidney disease patients are healthier and live
longer if they’ve beefed up their muscles, according to a study appearing in an
upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN). The results suggest that patients may benefit from pumping iron or taking medications to boost their lean body mass.

Low level of self-reported physical activity in ambulatory patients new to dialysis.

Kidney Int. 2010 Sep 1.

Johansen KL, Chertow GM, Kutner NG, Dalrymple LS, Grimes BA, Kaysen GA.
[1] Medical Service, Nephrology Section, San Francisco VA Medical Center, San Francisco, California, USA [2] Department of Medicine, University of California, San Francisco, California, USA.

Physical exercise among participants in the Dialysis Outcomes and Practice Patterns Study (DOPPS): correlates and associated outcomes.

Nephrol Dial Transplant. 2010 Apr 13.
Tentori F, Elder SJ, Thumma J, Pisoni RL, Bommer J, Fissell RB, Fukuhara S, Jadoul M, Keen ML, Saran R, Ramirez SP, Robinson BM.
Arbor Research Collaborative for Health, Ann Arbor, MI, USA.

Exercise in end-stage renal disease.

Segura-Orti E, Johansen KL.
Department of Physical Therapy, Universidad CEU-Cardenal Herrera, Valencia, Spain.
Semin Dial. 2010 Jul;23(4):422-30.

 

 
Author Interviews: hemodialysis - Dialysis - ESRD - CKD
Predictors of eGFR Decline in Type 2 Diabetes & Preserved Kidney Function: Dr. Chonchol CJASN
Tenecteplase for improvement of blood flow in dysfunctional hemodialysis catheters: Dr. Goldman Clin Neph
Religious coping, psychological distress and quality of life in hemodialysis: Dr. Carvalho J Psychosom Res. 
Effect of captopril on recuperation from ischemia/reperfusion-induced AKI Nephrology Dialysis Transplant
Restless legs syndrome in dialysis: comparison of hemodialysis & CAPD: Dr. Merlino Neurol Sci.
International practice patterns & non-conventional hemodialysis utilization : Dr. Sood BMC Nephrology 
Decreased PON1 in hemodialyzed & renal transplanted patients. Dr. Paragh Nephrol. Dial. Transplant
Preoperative Proteinuria & Long-Term Progression to Chronic Dialysis & Mortality after CABG: Drs. Chao & Ko : PLoS ONE
Creatinine generation is reduced in CVHD & predicts mortality: Dr. Wilson: Nephrology Dialysis Transplant
Importance of normohydration for the long-term survival in hemodialysis : Dr. Wabel
Nephrology Dialysis Transplant
Local Tissue Renin-Angiotensin System Activation in Cardiorenal Metabolic Syndrome & Type 2 Diabetes: Dr.Hayden Cardiorenal Med
Group I nonreciprocal inhibition in restless legs syndrome secondary to CKD : Dr. Marconi Parkinsonism & Related Disorders 
Low-Dose ESAs and CV Geometry in CKD: Is Darbepoetin-α More Effective than Expected? Dr. Di Lullo
Cardiorenal Med
Pharmacotherapy to improve outcomes in vascular access surgery: Dr. Jackson
Nephrology Dialysis Transplant
Parathyroidectomy for the attainment of NKF-K/DOQI™ and KDIGO recommended values for bone & mineral metabolism in dialysis with uncontrollable secondary hyperparathyroidism. Langenbecks Arch Surg
Bisphosphonate Therapy, Death, and Cardiovascular Events Among Female Patients With CKD: Dr. Perkins
Losartan prevents the development of the pro-inflammatory monocytes CD14+CD16+ in hemodialysis : Dr. Merino Nephrology Dialysis Transplant
Does Dialysis Modality Influence the Oxidative Stress of Uremia? Dr. Capusa  Kidney Blood Press Res
Treatment of Periodontal Diseases Reduces Inflammation in Hemodialysis : Dr. Siribamrungwong
Declining Rates of Deceased Donor Renal Transplantation in the US Over Successive Years of Listing: Dr. Trivedi
When Is the Best Moment to Assess the Ankle Brachial Index: Pre- or Post-Hemodialysis?Dr. RM Elias
Role of Race and Poverty on Steps to Kidney Transplantation in the Southeastern US
Validity & Reliability of the MUST and MST Nutrition Screening Tools in Renal Inpatients : C. Lawson
Target-Orientated Algorithm for Regional Citrate-Calcium Anticoagulation in Extracorporeal Therapies: Dr. Brandl
Evaluation of bone microarchitecture by HR-pQCT in hemodialysis : Dr. Negri
Erectile Dysfunction in Chronic Hemodialysis : Dr. Strippoli
Have Renal Dietitians Successfully Implemented Evidence-Based Guidelines Into Practice? E. Joy
Regional Citrate Versus Heparin Anticoagulation for CRRT: Drs. Tam & Wu
von Willebrand factor predicts mortality in CRRT : Dr. Péquériaux
Clinical Outcome of Twice-Weekly Hemodialysis Patients in Shanghai | Dr. Qian
Persistently low intact PTH levels predict aortic arch calcification progression in hemodialysis patients : Dr. Song
Lack of Awareness among Future Medical Professionals about the Risk of Consuming Hidden Phosphate-Containing Processed Food & Drinks : Dr. Razzaque
51Cr-EDTA plasma & urinary clearance as a measure of residual renal function in dialysis :Dr. Kjaergaard
Obesity and Mortality Risk among Younger Dialysis Patients: Dr. Hoogeveen
Solar-Assisted Hemodialysis: Dr. Agar
Hydrogen sulfide inhibits high glucose-induced matrix protein synthesis by activating AMP-activated protein kinase in renal epithelial cells Drs. Lee & Kasinath
Mineral, bone disorders, survival in hemodialysis with & without PKD : Drs. Molnar & Kalantar-Zadeh
Hydrogen sulfide inhibits high glucose-induced matrix protein synthesis by activating AMP-activated protein kinase in renal epithelial cells Drs. Lee & Kasinath
Mineral, bone disorders, survival in hemodialysis with & without PKD : Drs. Molnar & Kalantar-Zadeh
Downregulation of the renal & hepatic hydrogen sulfide-producing enzymes and capacity in CKD - Dr. Vaziri
A predictive algorithm for management of anemia in hemodialysis based on ESA pharmacodynamics : Dr. Lines
Factors Associated With Intradialytic Systolic Blood Pressure Variability: Dr. Flythe
Safety and predictors of complications of renal biopsy in the outpatient setting : Dr. Jiang
Heparin induced antibodies in chronic hemodialysis patients and cardiac surgery patients: Dr. Shavit
Atrial Fibrillation in Medicare/Medicaid-eligible dialysis patients: Dr. Wetmore
Newly identified anorexigenic adipokine nesfatin-1 in hemodialysis patients: J. Saldanha
Correction of Post kidney Transplant Anemia Reduces Progression of Allograft Nephropathy: Dr. Choukrou
Mild and moderate pre-dialysis CKD is associated with increased coronary artery calcium: Dr. Budoff
Endogenous factors modified by hemodialysis and accuracy of blood glucose-measuring device: Dr. Ogawa
Narrow-band UVV increases serum vitamin D levels in hemodialysis patients Dr. Ala-Houhala
Predicting hospital cost in CKD patients through blood chemistry values: Dr. Bessette
Nutritional vitamin D supplementation in hemodialysis: a potential vascular benefit? D. Mason
Volume excess in chronic hemodialysis effects of treatment frequency & treatment spacing : Dr. Schneditz
Acid reduction with fruits/veges or bicarb attenuates kidney injury in hypertensive nephropathy with reduced GFR
Predicting Number of US Medical Graduates Entering Adult Nephrology Fellowships
Using Search Terms Dr. Desai
Potential influence of sevelamer hydrochloride on responsiveness to ESAs in hemodialysis patients: Dr. Ikee
Anemia Management in Dialysis : ESAs vs Transfusions: Clinical & Economic Consequences :Dr. Naci
Increased risk of death and de novo chronic kidney disease following reversible acute kidney injury: Dr. Perkins
Filtration Markers May Have Prognostic Value Independent of Glomerular Filtration Rate : Dr. Tangri
Stopping Renin-Angiotensin System Inhibitors in Chronic Kidney Disease: Predictors of Response
Insights into nephrologist training, clinical practice, and dialysis choice: Dr. Mehrotra
Early ACE inhibition in Alport syndrome delays renal failure and improves life expectancy: Dr. Gross
Blunted insulinemia using high dialysate glucose concentration during hemodialysis : Dr. Schneditz
Prevalence of Inadequate Platelet Inhibition by Clopidogrel in Patients Receiving Hemodialysis: Dr. Alexopoulos
Live kidney donation: attitudes towards donor approach, motives and factors promoting donation: Dr. Mazaris
High-dose ESAs, inflammatory biomarkers, and soluble erythropoietin receptors : Dr. Inrig
Association of AKI with Adverse Outcomes in Burned Military Casualties : Dr. Stewart
Sodium Intake, ACE Inhibition, and Progression to ESRD Dr. Ruggenenti
DOPPS Practice Monitor: Update on Trends in US Hemodialysis Care Following Launch of Bundled Payment System and Revisions to ESA Labels January 6 2011

Emerging trends in hemodialysis care through August 2011, based on a sample of US dialysis facilities, are included in the latest update to the DOPPS Practice Monitor (DPM, at http://www.dopps.org/DPM), run by the Dialysis Outcomes and Practice Patterns Study (DOPPS) at Arbor Research Collaborative for Health.

Ongoing Changes in the US Dialysis Environment – Recent changes in dialysis payment and regulatory guidance are expected to affect hemodialysis practice. In January 2011, the Centers for Medicare & Medicaid Services (CMS) launched a new Prospective Payment System (PPS) with the intent to control dialysis costs through bundled payments. In June 2011, the FDA approved revised prescribing information for erythropoiesis-stimulating agents (ESAs), used to treat anemia in most dialysis patients. Previously, the label recommended a hemoglobin target range of 10-12 g/dL. The June 2011 update removed the target range, advising instead to start ESA therapy for dialysis patients at hemoglobin less than 10 g/dL, and to reduce or interrupt the dose when the hemoglobin approaches or exceeds 11 g/dL.

Most Recent Trends in Care – Over the August 2010 to August 2011 time period, many hemodialysis practices have remained stable; examples include nutrition measures and hemodialysis treatment time and dose. There have been notable trends in the following practice areas:

  • Anemia: Hemoglobin levels have decreased since the June 2011 ESA label update. While the mean hemoglobin level declined by 0.12 g/dL over 12 months from August 2010 to July 2011, it declined in August 2011 by another 0.10 g/dL to 11.26 g/dL. The percentage of patients with hemoglobin levels greater than 12 g/dL declined sharply (from 28% to 23%) in July/August 2011, while the percentage with hemoglobin levels less than 10 g/dL increased slightly from 8.5% to 10% and the percentage with hemoglobin levels less than 9 g/dL remained under 3%.

Mean prescribed epoetin dose (among patients receiving epoetin) decreased by 15%, from 21,100 units/wk to 17,900 units/wk, from August 2010 to August 2011, with the greatest decline in June-August 2011. Epoetin doses at the higher end of the dose range have decreased most notably. IV iron use increased from August 2010 to August 2011 though has recently stabilized. In keeping with greater IV iron use, serum ferritin levels (indicative of iron stores) continue to rise. Serum ferritin concentration exceeded 500 ng/mL in 65% of patients, 800 ng/mL in 34% of patients, and 1,200 ng/mL in 11% of patients in August 2011.

  • Mineral & Bone Disorder: In our last report, we noted a 29% increase in serum parathyroid hormone (PTH) levels through April 2011, and differences by race were described. Since then, PTH levels have remained stable or declined slightly in both black and non-black patients. In August 2011, 22% of black patients and 12% of non-black patients had very high PTH values (defined here as PTH >600 pg/mL). The percentage of hemodialysis patients for whom PTH is measured has declined slightly since August 2010. There have been no clear changes in serum calcium or serum phosphorus levels.
  • Clinical Outcomes: Preliminary data indicate that the 30-day hospitalization rate has increased somewhat from August 2010 to August 2011. The DPM does not report yet on trends in red blood cell transfusions, as dialysis units are often unaware of transfusions occurring in the inpatient setting. Additional efforts to comprehensively monitor trends in transfusions are warranted. To date mortality rate has not changed appreciably, though further follow-up time is necessary as we continue to track this outcome.

Future monitoring of these trends, confirmation with national data when eventually available, and understanding their effect on clinical outcomes, if any, is required.

DPM data are aggregated across dialysis organizations and facilities. Aggregated trends may not reflect trends in individual dialysis organizations or facilities, and are not intended to provide oversight of performance in individual dialysis organizations or facilities.

Read the rest of the DOPPS Practice Monitor: Update on Trends in US Hemodialysis Care Following Launch of Bundled Payment System and Revisions to ESA Labels Press Release

 
Hemodialysis Patient: Calciphylaxis after skin biopsy - Joerg Latus

Early Stages of Calciphylaxis:
Are Skin Biopsies the Answer?

Joerg Latus, MD
Open Access

Case Rep Dermatol 2011;3:201-205


 

Hemodialysis Research Interview of the Week

Author Interview: Dr. Len Usvyat PhD
Clinical Systems Database Senior Analyst
Renal Research Institute

Seasonal Variations in Mortality, Clinical, and Laboratory Parameters in Hemodialysis Patients: A 5-Year Cohort Study.

Usvyat LA, Carter M, Thijssen S, Kooman JP, van der Sande FM, Zabetakis P,
Balter P, Levin NW, Kotanko P.
 Clin J Am Soc Nephrol. 2011 Nov 17.

What are the main findings of the study?

We found that mortality of hemodialysis patients followed a seasonal pattern over a five year period with the highest mortality in the winter and lowest mortality in the summer months.

We also observed that many clinical and laboratory parameters follow a seasonal pattern in our patient population.

For example, pre-dialysis systolic blood pressures are highest in winter and lowest in summer months; pre-dialysis body temperatures are highest in summer and lowest in winter months.

Neutrophils are highest in winter and lowest in summer suggesting higher inflammatory markers in the winter.

This phenomena was observed in various geographic regions in US.

Were any of the findings unexpected?

It has been previously shown that mortality follows seasonal trends in healthy population however these findings were never extended to dialysis patients.

While it was shown that blood pressures tend to follow a seasonal pattern, to the best of our knowledge, it has not been shown that neutrophils or interdialytic weight gains also follow a seasonal pattern.

Additionally, we applied a cosinor analysis to show whether these patterns are statistically significant.

What should clinicians and patients take away from this study?

These findings are particularly important in designing studies -- taking season into account is key.

What recommendations do you have for future studies as a result of your study?

Further research into understanding the biologic factors that contribute to this seasonality is important.

 


 
 
 
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