Kidney function is a vital measure of overall health. The studies presented below evaluate the correlations between measurements of kidney function and overal risk of mortality.
The Lancet, Early Online Publication, 18 May 2010
doi:10.1016/S0140-6736(10)60674-5
New Feature from Hemodialysis.com: Hemodialysis or Chronic Kidney Disease Abstract of the Week
Association of Cumulatively Low or High Serum Calcium Levels with Mortality in Long-Term Hemodialysis Patients.
Am J Nephrol. 2010 Sep 3;32(5):403-413.
Miller JE, Kovesdy CP, Norris KC, Mehrotra R, Nissenson AR, Kopple JD, Kalantar-Zadeh K.
Harold Simmons Center for Kidney Disease Research and Epidemiology,Torrance, Calif., USA.
Abstract
Background: The outcome-predictability of baseline and instantaneously changing serum calcium in hemodialysis patients has been examined. We investigated the mortality-predictability of time-averaged calcium values to reflect the 'cumulative' effect of calcium burden over time. Methods: We employed a Cox model using up-to-5-year (7/2001-6/2006) time-averaged values to examine the mortality-predictability of cumulative serum calcium levels in 107,200 hemodialysis patients prior to the use of calcimimetics, but during the time where other calcium-lowering interventions, including lower dialysate calcium, were employed.
Results: Both low (<9.0 mg/dl) and high (>10.0 mg/dl) calcium levels were associated with increased mortality (reference: 9.0 to <9.5 mg/dl). Whereas mortality of hypercalcemia was consistent, hypocalcemia mortality was most prominent with higher serum phosphorus (>3.5 mg/dl) and PTH levels (>150 pg/ml).
Higher paricalcitol doses shifted the calcium range associated with the greatest survival to the right, i.e. from 9.0 to <9.5 to 9.5 to <10.0 mg/dl. African-Americans exhibited the highest death hazard ratio of hypocalcemia <8.5 mg/dl, being 1.35 (95% CI: 1.22-1.49). Both a rise and drop in serum calcium over 6 months were associated with increased mortality compared to the stable group.
Conclusions: Whereas in hemodialysis patients cumulatively high or low calcium levels are associated with higher death risk, subtle but meaningful interactions with phosphorus, PTH, paricalcitol dose and race exist.
Hemodialysis | Kidney Disease | Dialysis Resources and Educational Materials
100 Q&A About Kidney Disease and Hypertension
Raymond R. Townsend, MD
High blood pressure is one of the leading causes of kidney failure. Each year, high blood pressure causes more than 25,000 new cases of kidney failure in the United States. 100 Questions & Answers About Kidney Disease and Hypertension offers authoritative, up-to-date, practical answers about kidney disease, end-stage renal disease, transplants, and dialysis. The book is an invaluable resource for anyone coping with the physical and emotional turmoil of this condition.
Handbook of Dialysis Therapy
Here's an in-depth, quick-reference, problem-solving resource for those involved in the care of dialysis patients. More than 120 world-class authorities discuss dialysis techniques, mechanical considerations, and complications related to various diseases for both pediatric and adult patients. Selected annotated references and excellent cross-referencing between chapters help you find answers fast, and more than 100 photos, drawings, charts, and tables, mostly in color, clarify complex topics. Providing practical, immediately useful guidelines that can be applied directly to patient care, this book is a "must-have" for all dialysis caregivers.
Certified Hemodialysis Technologist/Technician Exam Secrets Study Guide: CHT Test Review for the Certified Hemodialysis Technologist/Technician Exam
Certified Hemodialysis Technologist/Technician Exam Secrets helps you ace the Certified Hemodialysis Technologist/Technician Exam, without weeks and months of endless studying. Our comprehensive Certified Hemodialysis Technologist/Technician Exam Secrets study guide is written by our exam experts.....
Dialysis and Hemodialysis Book and Descriptions from Amazon.com
Please visit the Hemodialysis.com Google Ad Sponsors
The information on Hemodialysis is for informational purposes only and is not intended as specific medical advice or to be a substitute for medical advice from your physician or health care provider. Please check with a physician if you need a diagnosis and/or for treatments as well as information regarding your specific condition.
Please read Medical Disclaimer as term of condition for usage of this website.
If you are experiencing urgent medical conditions, call 9-1-1
Copyright 2010 EminentDomains.com®. All Rights Reserved.
Our Success is Linked to Your Success®
