Mortality Studies in Dialysis Hemodialysis and Peritoneal Dialysis Patients

Hemodialysis.com Authors' Interview: Kunitoshi Iseki M.D.

Effects of angiotensin receptor blockade (ARB) on mortality and cardiovascular outcomes in patients with long-term haemodialysis: a randomized controlled trial

Kunitoshi Iseki, Hisatomi Arima, Kentaro Kohagura, Ichiro Komiya, Shinichiro Ueda, Kiyoyuki Tokuyama, Yoshiki Shiohira, Hajime Uehara, and Shigeki Toma
Effects of angiotensin receptor blockade (ARB) on mortality and cardiovascular outcomes in patients with long-term haemodialysis: a randomized controlled trial Nephrol. Dial. Transplant. first published online January 25, 2013 doi:10.1093/ndt/gfs590

Hemodialysis.com Authors' Interview: Charuhas V Thakar, MD, FASN

Degree of Acute Kidney Injury before Dialysis Initiation and Hospital Mortality in Critically Ill Patients

Charuhas V. Thakar, Annette Christianson, Peter Almenoff, Ron Freyberg, and Marta L. Render, “Degree of Acute Kidney Injury before Dialysis Initiation and Hospital Mortality in Critically Ill Patients,” International Journal of Nephrology, vol. 2013, Article ID 827459, 7 pages, 2013. doi:10.1155/2013/827459

Hemodialysis.com Authors' Interview: Dr. Salman Waheed and Dr. Joseph Coresh

Combined Association of Creatinine, Albuminuria, and Cystatin C with All-Cause Mortality and Cardiovascular and Kidney Outcomes

Salman Waheed, Kunihiro Matsushita, Brad C. Astor, Ron C. Hoogeveen, Christie Ballantyne, and Josef Coresh

CJASN CJN.04960512; published ahead of print December 20, 2012, doi:10.2215/CJN.04960512

Hemodialysis.com Author Interview: Dr. John Kyriazis

The Role of Serum Magnesium and Calcium on the Association between Adiponectin Levels and All-Cause Mortality in End-Stage Renal Disease Patients

Anastasia Markaki, John Kyriazis, Kostas Stylianou, George A. Fragkiadakis, Kostas Perakis, Andrew N. Margioris, Emmanuel S. Ganotakis, Eugene Daphnis
Research Article | published 20 Dec 2012 | PLOS ONE
10.1371/journal.pone.0052350

Hemodialysis.com Authors' Interview:
Dr. Belinda Spoto, CNR-IBIM and Dr. Carmine Zoccali CNR-IBIM

The fat-mass and obesity-associated gene (FTO) predicts mortality in CKD of various severity.

Belinda Spoto, Francesco Mattace-Raso, Eric Sijbrands, Francesca Mallamaci, Daniela Leonardis, Filippo Aucella, Alessandra Testa, Antonio Gesuete, Maria C. Sanguedolce, Graziella D'Arrigo, Rosa M. Parlongo, Anna Pisano, Claudia Torino, Giuseppe Enia, Giovanni Tripepi, Maurizio Postorino, and Carmine Zoccali

Nephrol. Dial. Transplant. (2012) 27(suppl 4): iv58-iv62 doi:10.1093/ndt/gfs550

Hemodialysis.com Author Interview: Dr. Connie Rhee MD MSc

Hypothyroidism and Mortality among Dialysis Patients
Rhee CM, Alexander EK, Bhan I, Brunelli SM.  Clin J Am Soc Nephrol. 2012 Dec 20. [Epub ahead of print]

Minako Wakasugi, M.D., M.P.H., Ph.D

Cause-Specific Excess Mortality Among Dialysis Patients: Comparison With the General Population in Japan

Wakasugi, M., Kazama, J. J., Yamamoto, S., Kawamura, K. and Narita, I. (2012), Cause-Specific Excess Mortality Among Dialysis Patients: Comparison With the General Population in Japan. Therapeutic Apheresis and Dialysis. doi: 10.1111/j.1744-9987.2012.01144.x

Hemodialysis.com Author Interview:
Ahsan Alam, MD, CM, MS, FRCP(C)

Serum Adiponectin Levels and Mortality after Kidney Transplantation.


Alam A, Molnar MZ, Czira ME, Rudas A, Ujszaszi A, Kalantar-Zadeh K, Rosivall L, Mucsi I.
Division of Nephrology, McGill University Health Centre, Montreal, Quebec, Canada;, †Institute of Pathophysiology and, ‡Institute of Behavioral Sciences, Semmelweis University, Budapest, Hungary;, §Harold Simmons Center for Chronic Disease Research & Epidemiology, University of California Irvine Medical Center, Irvine, California; Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California;, ?Department of Medicine, Division of Nephrology, University Health Network, University of Toronto, Toronto, Ontario, Canada, ¶Division of Nephrology & Hypertension, University of California Irvine Medical Center, Orange, California.

Clin J Am Soc Nephrol. 2012 Dec 6. [Epub ahead of print]

Hemodialysis.com Author Interview: Dr. Jessica Weiss

ASN 2012-PO246: The Relationship between Blood Pressure and Mortality in Older Adults with Chronic Kidney Disease is Modified by Age and Renal Function

Authors: Jessica W. Weiss, MD*1, Dawn Peters, PhD2, Xiuhai Yang, MS3; Amanda Petrik, MS3; David H. Smith, RPh, PhD3; Eric S. Johnson, PhD3; Micah L. Thorp DO, MPH3, Cynthia Morris, PhD MPH4; Ann M. O’Hare, MD5.

Hemodialysis.com Author Interview: Dr. Jessica Weiss

ASN 2012: FR-PO265: Differential Risk of ESRD versus Death in Black versus White Veterans is attenuated by Older Age and Lower Levels of Kidney Function

Authors: Jessica W. Weiss, MD*1, Thy Do, PhD2, Adam J. Batten, BA2, Yoshio N. Hall, MD2, and Ann M. O'Hare, MD2.

Affiliations: 1Div. Nephrology, Oregon Health and Science University, Portland, OR, United States; 2Div. Nephrology, University of Washington, VA Puget Sound Healthcare System, Seattle, WA, United States

Hemodialysis.com Authors' Interview: Stein Hallan, MD PhD

Age and Association of Kidney Measures With Mortality and ESRD

Hallan SI, Matsushita K, Sang Y, et al. JAMA. 2012;():1-12. doi:10.1001/jama.2012.16817.

Hemodialysis.com Authors' Interview Ethan Bohn, Dr. Claudio Rigatto

Abstract: [SA-PO599] Predicting Mortality in Dialysis Patients: Does a Simple Chest X-Ray Have Prognostic Value?

Ethan Bohn, Brent Gali, Navdeep Tangri, MD, Manish M. Sood, MD, Paul Komenda, MD, Claudio Rigatto, MD. University of Manitoba, Winnipeg, Canada. 

Hemodialysis.com Author Interview: Hamid Moradi, MD

Hypercholesterolemia and Hypertriglyceridemia Are Associated with Better Survival in Hemodialysis Patients

Hamid Moradi, MD, FASN, Elani Streja, Hamid M. Said, PhD, Madeleine V. Pahl, MD, FASN, Nosratola D. Vaziri, MD, Kamyar Kalantar-Zadeh, MD, PhD, FASN. Medicine, University of California, Irvine, Orange, CA; Harold Simmons Center, LA BioMed, Harbor-UCLA, Torrance, CA; Medicine, University of California, Los Angeles, Los Angeles, CA.

Hemodialysis.com Author Interview:

Jochen G. Raimann, Renal Research Institute, New York 10128,

Early Systolic Blood Pressure Changes in Incident Hemodialysis Patients Are Associated with Mortality in the First Year.


Sipahioglu MH, Usvyat L, Liu L, Abbas SR, Raimann JG, Rosales L, Levin NW, Kotanko P.
Department of Nephrology, Medical Faculty, Erciyes University, Kayseri, Turkey.
Kidney Blood Press Res. 2012 Oct 19;35(6):663-670. [Epub ahead of print]

Hemodialysis.com Authors' Interview:

Dr. Tanvir Chowdhury Turin
Dr. Brenda R Hemmelgarn

[SA-PO192] Association between Variability in eGFR and Mortality

Tanvir Chowdhury Turin, MBBS, Min Jun, PhD, Marcello Tonelli, MD, Braden J. Manns, MD, Hiddo Jan Lambers Heerspink, PhD, Vlado Perkovic, MBBS, FASN, Brenda Hemmelgarn, MD, PhD. University of Calgary, Canada; University of Sydney, Australia; University of Alberta, Canada; University of Groningen, Netherlands.

Hemodialysis.com Author Interview: Mara McAdams DeMarco, PhD

Activity of Daily Living Disability and Dialysis Mortality: Better Prediction Using Metrics of Aging

McAdams-DeMarco, M. A., Law, A., Garonzik-Wang, J. M., Gimenez, L., Jaar, B. G., Walston, J. D. and Segev, D. L. (2012), Journal of the American Geriatrics Society, 60: 1981–1982. doi: 10.1111/j.1532-5415.2012.04161.x

Hemodialysis.com Author Interview: Dr. Robert Nelson, MD, PhD

Associations of kidney disease measures with mortality and ESRD in individuals with and without diabetes: a meta-analysis

Caroline S Fox MD,Kunihiro Matsushita MD,Prof Mark Woodward PhD,Prof Henk JG Bilo MD,Prof John Chalmers MD,Hiddo J Lambers Heerspink PharmD,Brian J Lee MD,Robert M Perkins MD,Prof Peter Rossing MD,Toshimi Sairenchi PhD,Prof Marcello Tonelli MD,Joseph A Vassalotti MD,Kazumasa Yamagishi MD,Prof Josef Coresh MD,Prof Paul E de Jong MD,Chi-Pang Wen MD,Robert G Nelson MD,for the Chronic Kidney Disease Prognosis Consortium
The Lancet - 24 September 2012
DOI: 10.1016/S0140-6736(12)61350-6

Hemodialysis.com Authors' Interview:

Professor Josef Coresh, MD, PhD, MHS and
Bakhtawar K Mahmoodi MD PhD

Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without hypertension: a meta-analysis


Bakhtawar K Mahmoodi MD,Kunihiro Matsushita MD,Prof Mark Woodward PhD,Prof Peter J Blankestijn MD,Massimo Cirillo MD,Takayoshi Ohkubo MD,Prof Peter Rossing MD,Prof Mark J Sarnak MD,Bénédicte Stengel MD,Kazumasa Yamagishi MD,Kentaro Yamashita MD,Luxia Zhang MD,Prof Dr Josef Coresh MD,Prof Paul E de Jong MD,Brad C Astor PhD,for the Chronic Kidney Disease Prognosis Consortium
The Lancet - 24 September 2012
DOI: 10.1016/S0140-6736(12)61272-0

Hemodialysis.com Authors' Interview:

Kamyar Kalantar-Zadeh, MD, MPH, PHD and Miklos Zsolt Molnar, MD, PhD

Administered paricalcitol dose and survival in hemodialysis patients: A marginal structural model analysis.
Miller, J. E., Molnar, M. Z., Kovesdy, C. P., Zaritsky, J. J., Streja, E., Salusky, I., Arah, O. A. and Kalantar-Zadeh, K. (2012), Administered paricalcitol dose and survival in hemodialysis patients: A marginal structural model analysis. Pharmacoepidem. Drug Safe.. doi: 10.1002/pds.3349

Hemodialysis.com Authors' Interview:

Habitual Physical Activity Measured by Accelerometer and Survival in Maintenance Hemodialysis Patients
Ryota Matsuzawa, Atsuhiko Matsunaga, Guoqin Wang, Toshiki Kutsuna, Akira Ishii, Yoshifumi Abe, Yutaka Takagi, Atsushi Yoshida, and Naonobu Takahira
CJASN CJN.03660412; published ahead of print September 13, 2012, doi:10.2215/CJN.03660412Published online before print September 2012, doi: 10.2215/?CJN.03660412  CJASN September

Hemodialysis.com Author Interview: Shih-Yi Lin

Association of response to hepatitis B vaccination and survival in dialysis patients
lin S, liu J, Wang S, Wang I, Tsai C, Liu Y, Lin H, Chang C, Huang C
BMC Nephrology 2012, 13:97 (30 August 2012)

Hemodialysis.com Author Interview: Dr. Tanvir Chowdhury Turin

Chronic kidney disease and life expectancyMortality_studies_in_dialysis_hemodialysis_peritoneal_dialysis_patients.
Turin TC, Tonelli M, Manns BJ, Ravani P, Ahmed SB, Hemmelgarn BR.
Nephrol Dial Transplant. 2012 Mar 22. [Epub ahead of print]

Greater variability in kidney function is associated with an increased risk of death

Ziyad Al-Aly, Sumitra Balasubramanian, Jay R McDonald, Jeffrey F Scherrer and Ann M O'Hare
Kidney Int advance online publication, August 1, 2012; doi:10.1038/ki.2012.276

Author Interview Dr. David Tovbin

Circulating cell-free DNA in hemodialysis patients predicts mortality

David Tovbin, Victor Novack, Maya Paryente Wiessman, Amir Abd Elkadir,
Moshe Zlotnik, and Amos Douvdevani

 Nephrol. Dial. Transplant. first published online July 24, 2012 doi:10.1093/ndt/gfs255

Change in SF-36 Summary Scores & Dialysis Survival

Eduardo Lacson, Jr., Nien-Chen Li, Shu-Fang Lin, Sandie Guerra-Dean, Michael Lazarus, Raymond Hakim, Franklin Maddux.
Fresenius Medical Care, North America, Waltham, MA, USA

Authors’ Interview: †Szu-Chun Hung, MD, and *Prof. Der-Cherng Tarng, MD, PhD

Decoy Receptor 3, a Novel Inflammatory Marker, and Mortality in Hemodialysis Patients

Clin J Am Soc Nephrol 2012 May 28. [Epub ahead of print]
Szu-Chun Hung, Ta-Wei Hsu, Yao-Ping Lin, Der-Cherng Tarng
Division of Nephrology, Buddhist Tzu Chi General Hospital,
Taipei Branch, Department and Institute of Physiology,
National Yang-Ming University, and Division of Nephrology and Immunology Research Center,
Taipei Veterans General Hospital, Taipei, Taiwan

Author Interview: Dr Lisa Hamzah
Baseline Kidney Function as Predictor of Mortality and Kidney Disease Progression in HIV-Positive Patients

Ibrahim F, Hamzah L, Jones R, Nitsch D, Sabin C, Post FA; UK Collaborative HIV Cohort (CHIC)/CKD Study Group.

King's College London, United Kingdom.

Am J Kidney Dis. 2012 Apr 20. [Epub ahead of print]

Author Interview: Sijie Zheng MD

Death Within 90 Days: Comparison of Mortality Rate Between Hemodialysis and Peritoneal Dialysis Patients

NKF Spring 2012 Abstract Presentation:
Sijie Zheng, Lue-Yen Tucker, David Law, Juan Ordonez. Kaiser Oakland Medical Center,
Division of Research, Oakland, California, USA

Author interview: Dr. Stephanie Thompson on behalf of Dr. Marcello Tonelli

Higher mortality among remote compared to rural or urban dwelling hemodialysis patients in the United States

Stephanie Thompson, John Gill, Xiaoming Wang, Raj Padwal, Rick Pelletier, Aminu Bello, Scott Klarenbach and Marcello Tonelli
Kidney International , (16 May 2012) | doi:10.1038/ki.2012.167

Author Interview: Vince Faridan MD Salem VA Medical Center, Salem VA

Association of Serum Sodium Levels with Mortality in Non-Dialysis Dependent Chronic Kidney Disease 

NKF Spring 2012 Presentation:

Vince Faridani, Jun L Lu, Kamyar Kalantar-Zadeh, Csaba P Kovesdy, Virginia Tech
Carilion School of Medicine, Roanoke, VA; Salem Research

Author Interview: Michel Chonchol, MD

Association of Complete Recovery From Acute Kidney Injury With Incident CKD Stage 3 and All-Cause Mortality

Jason Jones, John Holmen, Jennifer De Graauw, Anna Jovanovich, Sid Thornton, Michel Chonchol 
American Journal of Kidney Diseases - 30 April 2012 (10.1053/j.ajkd.2012.03.014

Author Interview: Kerri Cavanaugh, MD MHS
Rural and Micropolitan Residence and Mortality in Patients on Dialysis

  • Saugar Maripuri, Patrick Arbogast, T. Alp Ikizler, and Kerri L. Cavanaugh

    CJASN
     CJN.10831011; published ahead of print April 19, 2012,doi:10.2215/CJN.10831011

Author Interview:  Assist. Prof. Robert Ekart, MD, PhD
Prognostic Value of 48-Hour Ambulatory Blood Pressure Measurement and Cardiovascular Mortality in Hemodialysis Patients
.

Ekart R, Kani? V, Pe?ovnik Balon B, Bevc S, Hojs R.

Department of Dialysis, Clinic for Internal Medicine, University Medical Centre Maribor, Maribor, Slovenia.
Kidney Blood Press Res. 2012 Mar 7;35(5):326-331. [Epub ahead of print]

Author Interview: Drs. Miklos Z Molnar and Kamyar Kalantar-Zadeh
Mortality Prediction by Surrogates of Body Composition: An Examination of the Obesity Paradox in Hemodialysis Patients Using Composite Ranking Score Analysis.

Kamyar Kalantar-Zadeh, Elani Streja, Miklos Z. Molnar, Lilia R. Lukowsky,Mahesh Krishnan, Csaba P. Kovesdy, and Sander Greenland

Am. J. Epidemiol. first published online March 16, 2012 doi:10.1093/aje/kwr384

Finnian R. Mc Causland, Sushrut S. Waikar, Steven M., Brunelli

Increased dietary sodium is independently associated with greater mortality among prevalent hemodialysis patients


Finnian R. Mc Causland, Sushrut S. Waikar, Steven M., Brunelli
Kidney International
 , (14 March 2012) | doi:10.1038/ki.2012.4

Author Interview: Alberto Pilotto, MD

Addition of the multidimensional prognostic index to the estimated glomerular filtration rate improves prediction of long-term all-cause mortality in older patients with chronic kidney disease.

Alberto Pilotto, Daniele Sancarlo, Filippo Aucella, Andrea Fontana, Filomena Addante, Massimiliano Copetti, Francesco Panza, Giovanni F.M. Strippoli, and Luigi Ferrucci. Rejuvenation Research.
February 2012, 15(1): 82-88. doi:10.1089/rej.2011.1210.

Author Interview: Gregory C. Shearer, PhD


Gregory C. Shearer, Juan J. Carrero, Olof Heimbürger, Peter Barany, Peter Stenvinkel 

Journal of Renal Nutrition - March 2012 (Vol. 22, Issue 2, Pages 277-283,
DOI: 10.1053/j.jrn.2011.05.005)


Dr. Miklos Z Molnar MD, PhD and Dr. Kam Kalantar-Zadeh MD, MPH, PhD
Harold Simmons Center at Harbor-UCLA.

Mortality Associated with Dose Response of Erythropoiesis-Stimulating Agents in Hemodialysis versus Peritoneal Dialysis Patients

Duong U, Kalantar-Zadeh K, Molnar MZ, Zaritsky JJ,
Teitelbaum I, Kovesdy CP, Mehrotra R: 
 
Am J Nephrol 2012;35:198-208 (DOI: 10.1159/000335685)

Author Interview: Ho Sik Shin M.D. 

Geriatric Nutritional Risk Index May Be a Significant Predictor of Mortality in Korean Hemodialysis Patients: A Single Center Study.

Park, J. H., Kim, S. B., Shin, H. S., Jung, Y. S. and Rim, H. (2012), Geriatric Nutritional Risk Index May Be a Significant Predictor of Mortality in Korean Hemodialysis Patients: A Single Center Study. Therapeutic Apheresis and Dialysis. doi: 10.1111/j.1744-9987.2011.01046.x

Author Interview: Chia-Jui Tsa

The correlation of antidepressive agents and the mortality of end-stage renal disease: a Health Insurance Research Database Study in Taiwan

Chia-Jui Tsai, El-Wui Loh, Ching-Heng Lin, Tung-Min Yu, Chin-Hong Chan and Tsuo-Hung Lan
Accepted manuscript online: 19 JAN 2012 09:45PM EST |
DOI: 10.1111/j.1440-1797.2012.01571.x

Author Interview: Eduardo Lacson, Jr., MD, MPH, FACP, FASN

Depressive symptoms associate with high mortality risk and dialysis withdrawal in incident hemodialysis patients

Eduardo Lacson, Jr, Nien-Chen Li, Sandie Guerra-Dean, Michael Lazarus,
Raymond Hakim, and Fredric O. Finkelstein
Nephrol. Dial. Transplant. first published online January 23, 2012 doi:10.1093/ndt/gfr778

Author Interview: Drs. Ting-Ting Chao and Wen-Je Ko

Preoperative Proteinuria Is Associated with Long-Term Progression to Chronic Dialysis and Mortality after Coronary Artery Bypass Grafting Surgery.

Wu V-C ,  Huang T-M ,  Wu P-C ,  Wang W-J ,  Chao C-T ,  et al PLoS ONE 7(1): e27687. doi:10.1371/journal.pone.0027687 2012

Author Interview: Dr. Peter Wabel

Importance of normohydration for the long-term survival of haemodialysis patients


Charles Chazot, Peter Wabel, Paul Chamney, Ulrich Moissl,
 Sebastian Wieskotten,and Volker Wizemann

Nephrol. Dial. Transplant. first published online January 17, 2012 doi:10.1093/ndt/gfr678

Author Interview: Nathalie C. Péquériaux

Plasma concentration of von Willebrand factor predicts mortality in patients on chronic renal replacement therapy

Nathalie C. Péquériaux, Rob Fijnheer, Eugenie F. Gemen, Arjan D. Barendrecht, Friedo W. Dekker, Raymond T. Krediet, Jaap J. Beutler, Elisabeth W. Boeschoten, and Mark Roest

Nephrol. Dial. Transplant. first published online December 20, 2011 doi:10.1093/ndt/gfr735

Author Interview: Dr. Ellen K. Hoogeveen

Obesity and Mortality Risk among Younger Dialysis Patients

Ellen K. Hoogeveen, Nynke Halbesma, Kenneth J. Rothman, Theo Stijnen, Sandra van Dijk, Friedo W. Dekker, Elisabeth W. Boeschoten, Renée de Mutsert for the Netherlands Cooperative Study on the Adequacy of Dialysis-2, 
(NECOSAD) Study, and Group
CJN.05700611; published ahead of print January 5, 2012,doi:10.2215/CJN.05700611

ASN 2011 Abstract Authors' Interview:

Effect of Oral Nutritional Supplements on Mortality in Hemodialysis Patients.

Eduardo Lacson, Jr., MD, MPH, Weiling Wang, MS, Barbara Zebrowski, RD, Michael Lazarus, MD, Raymond Hakim, MD, PhD. Fresenius Medical Care, Waltham, MA.

Author Interview: Sirin Jiwakanon, MD.

Change in Ankle-Brachial Indices over Time and Mortality in Diabetics with Proteinuria
ASN 2011 Abstract:
Sirin Jiwakanon, MD, Sharon G. Adler, MD, FASN, Rajnish Mehrotra, MD, FASN. Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA, Torrance, CA; Medicine, Hatyai Hospital, Hatyai, Songkhla, Thailand.

Author Interview: Dr. Len Usvyat PhD

Predictive Characteristics of Successful Hemodialysis Patient Survival in the First 120 Days of Treatment

 ASN 2011Abstract: [SA-PO3024]


Len A. Usvyat, Penny Faith Palmiero, Lizette Borges, Lisa A. Pacelli, Mary T. Sullivan, Paul Balter, MD, Peter Kotanko, MD, Paul M. Zabetakis, MD.
Renal Research Institute, NY, NY.

Author Interview: Dr. Len Usvyat PhD

Seasonal Variations in Mortality, Clinical, and Laboratory Parameters in Hemodialysis Patients: A 5-Year Cohort Study.


Usvyat LA, Carter M, Thijssen S, Kooman JP, van der Sande FM, Zabetakis P, Balter P, Levin NW, Kotanko P.
 Clin J Am Soc Nephrol. 2011 Nov 17. [Epub ahead of print]

Author Interview: Dr. Kamyar Kalantar-Zadeh

Novel Lipoprotein Subfraction and Size Measurements in Prediction of Mortality in Maintenance Hemodialysis Patients

Nazanin Noori, Michael P. Caulfield, Wael A. Salameh, Richard E. Reitz, Susanne B. Nicholas, Miklos Z. Molnar, Allen R. Nissenson, Csaba P. Kovesdy, and Kamyar Kalantar-Zadeh

CJASN October 27, 2011 CJN.03650411; published ahead of print October 27, 2011, doi:10.2215/CJN.03650411

Author Interview: Drs. Marcelo Sampaio and Kam Kalantar-Zadeh

Association of Pretransplant Serum Phosphorus with Posttransplant Outcomes


Marcelo S. Sampaio,  Miklos Z. Molnar, Csaba P. Kovesdy, Rajnish Mehrotra, Istvan Mucsi, John J. Sim, Mahesh Krishnan, Allen R. Nissenson, and Kamyar Kalantar-Zadeh
CJASN September 29, 2011

Author Interview: Srini Beddhu, MD

High dietary fiber intake is associated with decreased inflammation and all-cause mortality in patients with chronic kidney disease

Krishnamurthy VM, Wei G, Baird BC, Murtaugh M, Chonchol MB, Raphael KL, Greene T, Beddhu S.Abstract
Kidney Int. 2011 Oct 19. doi: 10.1038/ki.2011.355.

Author Interview: Dr. Miklos Zsolt Molnar, MD, PhD

Serum Erythropoietin Level and Mortality in Kidney Transplant Recipients.

Molnar MZ, Tabak AG, Alam A, Czira ME, Rudas A, Ujszaszi A, Beko G, Novak M, Kalantar-Zadeh K, Kovesdy CP, Mucsi I.
Clin J Am Soc Nephrol. 2011 Oct 6. [Epub ahead of print]

Hemodialysis.com Author Interview: Dr. Simonetta Genovesi

Dipyridamole stress echocardiography in diagnosis and prognosis of hemodialysis patients with asymptomatic coronary disease

Rivera, R. F., Mircoli, L., Bonforte, G., Torri, V., Monteforte, M., Stella, A. and Genovesi, S.
Hemodialysis International 2011. doi: 10.1111/j.1542-4758.2011.00572.x

Author Interview: Michel Chonchol, MD

FGF-23 Associates with Death, Cardiovascular Events, and Initiation of Chronic Dialysis

Jessica Kendrick, Alfred K. Cheung , James S. Kaufman,Tom Greene,
William L. Roberts, Gerard Smits, Michel Chonchol, and the HOST Investigators JASN Sep 7, 2011 ASN.2010121224; published ahead of print September 7, 2011, doi:10.1681/ASN.2010121224

Author Interview: Dr Ilia Beberashvili MD

IL-6 Levels, Nutritional Status, and Mortality in Prevalent Hemodialysis Patients.

Beberashvili I, Sinuani I, Azar A, Yasur H, Shapiro G, Feldman L, Averbukh Z, Weissgarten J.
Clin J Am Soc Nephrol. 2011 Aug 18

Author Interview: Dr. Robert L Hanson MD

Albuminuria and Estimated Glomerular Filtration Rate as Predictors of Diabetic End-Stage Renal Disease and Death.

Berhane AM, Weil EJ, Knowler WC, Nelson RG, Hanson RL.
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona.
Clin J Am Soc Nephrol. 2011 Aug 18

Author Interview:  Chih-Chiang, Chien, MD 

Predictors of Longterm Mortality in Patients with and without Systemic Lupus Erythematosus on Maintenance Dialysis: A Comparative Study.

Chen HA, Wang JJ, Chou CT, Chien CC, Chu CC, Sheu MJ, Lin YJ, Chen PC, Chen CHFrom Chi-Mei Medical Center, Tainan; Buddhist Tzu Chi General Hospital, Taipei Branch; and Taipei Veterans General Hospital, Taipei, Taiwan.
Rheumatol. 2011 Aug 15

An interview with Drs. Miklos Z Molnar and Kamyar Kalantar-Zadeh from Harbor-UCLA

High platelet count as a link between renal cachexia and cardiovascular mortality in end-stage renal disease patients.

Molnar MZ, Streja E, Kovesdy CP, Budoff MJ, Nissenson AR, Krishnan M, Anker SD, Norris KC, Fonarow GC, Kalantar-Zadeh K.
Harold Simmons Center for Chronic Disease Research & Epidemiology, Los Angeles Biomedical Research Institute at Harbor-University of California Los Angeles Medical Center, Torrance, CA.
Am J Clin Nutr. 2011 Aug 3

Authors' Interview:
Drs. Nazanin Noori  MD Ph.D & Kamyar Kalantar-Zadeh, MD, MPH, PhD

Dietary Omega-3 Fatty Acid, Ratio of Omega-6 to Omega-3 Intake, Inflammation, and Survival in Long-term Hemodialysis Patients.

Noori N, Dukkipati R, Kovesdy CP, Sim JJ, Feroze U, Murali SB, Bross R, Benner D, Kopple JD, Kalantar-Zadeh K.
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA; Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA.
Am J Kidney Dis. 2011 Jun 7.

Author Interview: Dr. Martin Wagner, MD MS

Endogenous erythropoietin and the association with inflammation and mortality in diabetic chronic kidney disease.

Wagner M, Alam A, Zimmermann J, Rauh K, Koljaja-Batzner A, Raff U, Wanner C, Schramm L.
Clin J Am Soc Nephrol. 2011 Jul;6(7):1573-9.
University Hospital Würzburg, Department of Medicine I, Division of Nephrology, Zentrum Innere Medizin, Oberdürrbacher Strasse 6, 7080 Würzburg, Germany

Author Interview: Dr. Qionghong Xie
The Ratio of CRP to Prealbumin Levels Predict Mortality in Patients with Hospital-acquired Acute Kidney Injury


Xie Q, Zhou Y, Xu Z, Yang Y, Kuang D, You H, Ma S, Hao C, Gu Y, Lin S, Ding F 
 BMC Nephrol 2011 Jun 29; 12(1):30.
Author Interview: Dr. Tobias Breidthardt
Increasing B-type natriuretic peptide levels predict mortality in unselected haemodialysis patients.
Authors: Breidthardt T, Kalbermatter S, Socrates T, Noveanu M, Klima T, Mebazaa A, Mueller C, Kiss D
Eur J Heart Fail. 2011 May 30
Author Interview: Dr. Biagio Di Iorio
Variability of pulse wave velocity and mortality in chronic hemodialysis patients
.

Torraca S, Sirico ML, Guastaferro P, Morrone LF, Nigro F, Blasio AD, Romano P, Russo D, Bellasi A, Di Iorio B Hemodial Int. 2011 Apr 25. doi: 10.1111/j.1542-4758.2011.00545.x.
SOC di Nefrologia, Solofra, Avellino, Italy SOC di Nefrologia, Sant'Angelo dè Lombardi, Avellino, Italy SOC di Nefrologia, Benevento, Italy SOC di Nefrologia, Azienda Universitaria "FEDERICO II," Napoli, Italy SOC di Nefrologia, Malpighi Hospital, Bologna, Italy

Author Interview: Dr. Jin-Bor Chen
Mitochondrial DNA copy number correlates with oxidative stress and predicts mortality in nondiabetic hemodialysis patients

Yi-Chun Wang, Wen-Chin Lee, Shang-Chih Liao, Lung-Chih Lee, Yu-Jen Su, Chien-Te Lee,
Jin-Bor Chen
J Nephrol 2011; 24(3): 351 - 358

Author Interview: Barry I. Freedman, M.D.
Glycated Albumin and Risk of Death and Hospitalizations in Diabetic Dialysis Patients.


Freedman BI, Andries L, Shihabi ZK, Rocco MV, Byers JR, Cardona CY, Pickard MA, Henderson DL, Sadler MV, Courchene LM, Jordan JR, Balderston SS, Graham AD, Mauck VL, Russell GB, Bleyer AJ.
Clin J Am Soc Nephrol. 2011 May 19.
Author Interview: Dr Clec'h Christophe, MD, PhD
Multiple-center evaluation of mortality associated with acute kidney injury in critically ill patients: a competing risks analysis.


Crit Care. 2011 May 17;15(3):R128.
Clec'h C, Gonzalez F, Lautrette A, Nguile-Makao M, Garrouste-Orgeas M, Jamali S, Goldgran-Toledano D, Descorps-Declere A, Chemouni F, Hamidfar-Roy R, Azoulay E, Timsit JF

Author Interview: Dr. Allen R. Nissenson
Dialyzer Reuse and Peracetic Acid and Patient Mortality

T. Christopher Bond, Allen R. Nissenson,   Mahesh Krishnan, Steven M. Wilson,
Tracy Mayne
CJASN May 2011 CJN.10391110

Author Interview: Teresa Adragão
Ankle—brachial index, vascular calcifications and mortality in dialysis patients

Teresa Adragao, Ana Pires,  Patrícia Branco,  Rui Castro,  Ana Oliveira, Cristina Nogueira, Joaquim Bordalo,  José Dias Curto,  and Mateus Martins Prata
Nephrol. Dial. Transplant. (2011) doi: 10.1093/ndt/gfr233

Author Interview Dr. Martin Wagner MD MD
Predicting Mortality in Incident Dialysis Patients: An Analysis of the United Kingdom Renal Registry


Am J Kidney Dis. 2011 Apr 11;
Authors: Wagner M, Ansell D, Kent DM, Griffith JL, Naimark D, Wanner C, Tangri N

Author Interview: Dr. Dorien M. Zelle,
Low Physical Activity and Risk of Cardiovascular and All-Cause Mortality in Renal Transplant Recipients


Dorien M. Zelle, Eva Corpeleijn,  Ronald P. Stolk, Mathieu H.G. de Greef, Rijk O.B. Gans, Jaap J. Homan van der Heide, Gerjan Navis, and Stephan J.L. Bakker

Dr. Dorien M. Zelle, Department of Nephrology, University Medical Center Groningen, Sector A, PO Box 30001, 9700 RB, Groningen, The Netherlands
CJASN April 2011 6):(4)898-905, doi:10.2215/CJN.03340410

Author Interview: Dr. Hiroyuki Inoshita, M.D., Ph.D.
Complement in patients receiving maintenance hemodialysis: functional screening and quantitative analysis.

Inoshita H, Ohsawa I, Kusaba G, Ishii M, Onda K, Horikoshi S, Ohi H, Tomino Y.
BMC Nephrol. 2010 Dec 6;11:34.
Division of Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan.

Nasal Carriage of Methicillin-resistant Staphylococcus aureus Is Associated with Higher All-Cause Mortality in Hemodialysis Patients.

Clin J Am Soc Nephrol. 2011 Jan;6(1):167-74.

Lai CF, Liao CH, Pai MF, Chu FY, Hsu SP, Chen HY, Yang JY, Chiu YL, Peng YS, Chang SC, Hung KY, Tsai TJ, Wu KD.
Department of Internal Medicine, Far Eastern Memorial Hospital, No. 21, Nan-Ya South Road, Ban Ciao City, Taipei, 220, Taiwan

Long-Term Morbidity and Mortality Related to Falls in Hemodialysis Patients: Role of Age and Gender - A Pilot Study.

Nephron Clin Pract. 2011 Jan 7;118(3):c278-c284

Abdel-Rahman EM, Yan G, Turgut F, Balogun RA.
Division of Nephrology, Department of Medicine, University of Virginia Health System, Charlottesville, Va.

Mortality associated with low serum sodium concentration in maintenance hemodialysis.

Am J Med. 2011 Jan;124(1):77-84.

Waikar SS, Curhan GC, Brunelli SM.
Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.

The Effect of Dialysis Chains on Mortality among Patients Receiving Hemodialysis
Zhang, Y., Cotter, D. J. and Thamer, M.
Health Services Research, doi: 10.1111/j.1475-6773.2010.01219.xDecember 2010

Association between estimated glomerular filtration rate at initiation of dialysis and mortality

Published online ahead of print December 6, 2010
CMAJ 10.1503/cmaj.100349

William F. Clark, et al

Background: : Recent studies have reported a trend toward earlier initiation of dialysis (i.e., at higher levels of glomerular filtration rate) and an association between early initiation and increased risk of death. We examined trends in initiation of hemodialysis within Canada and compared the risk of death between patients with early and late initiation of dialysis.

Author Interview: Dr. William F. Clark Association between estimated glomerular filtration rate at initiation of dialysis and mortality

Increased Hospital Admissions on Mondays and Tuesdays in Hemodialysis Patients

Eduardo K. Lacson, Shu-Fang Lin, J. Michael Lazarus, Raymond M. Hakim. Fresenius Medical Care, North America, Waltham, MA

Introduction: Sudden deaths in hemodialysis (HD) patients occur more frequently on Mondays and Tuesdays, after the longest interdialytic period on a thrice weekly treatment schedule (3Tx/Wk). We hypothesized that hospitalization for all causes and more specifically for conditions due to fluid overload occur in a similar pattern.

Height constitutes an important predictor of mortality in end-stage renal disease.

Takenaka T, Sato T, Hoshi H, Kato N, Sueyoshi K, Tsuda M, Watanabe Y, Takane H,
Cardiol Res Pract. 2010 Nov 11;2011:242353.

Ohno Y, Suzuki H.
Department of Medicine, Saitama Medical College, 38 Moro-hongo, Moroyama, Iruma, Saitama 395-0495, Japan

Incremental value of a combination of cardiac troponin T, N-terminal pro-brain natriuretic peptide and C-reactive protein for prediction of mortality in end-stage renal disease.

Scand J Urol Nephrol. 2010 Nov 22.

Hallén J, Madsen L, Ladefoged S, Fagerland MW, Serebruany VL, Agewall S, Atar D.
Department of Cardiology, Oslo University Hospital, Aker and Ullevaal, Oslo, Norway.

Catheter Reduction Reduces Hospitalization and Mortality

Renee Jg Arnold, David Madigan, John A. Robertson, Abbe Volz. DaVita Inc., Denver, CO
Date: Friday, November 19, 2010

Introduction: Use of central venous catheters (CVC) in hemodialysis patients is associated with increased hospitalization and mortality. Published data have shown that an aggressive catheter reduction initiative (CathAway™) can decrease both catheter incidence and duration. We examined the impact of CathAway™ on hospitalization and mortality in the last 15 months of this program.

Read the Author Interview:
Catheter Reduction Reduces Hospitalization and Mortality

Discriminators of Death and Survival in the First Year of Hemodialysis: Threshold Values and Hierarchical Importance – The United States Renal Data System (USRDS)

Robert N. Foley, Allan J. Collins. USRDS Coordinating Center, MMRF, Minneapolis, MN; Medicine, University of MN, Minneapolis, MN
10:00 AM - 2:30 PM

High first year mortality is an ongoing public health issue in the US. In this regard, knowing optimally discriminating threshold values of suspected risk factors, high-yield subgroups and hierarchical importance could help gauge the appropriateness of renal replacement therapy and identify interventions

Early Start of Hemodialysis May Be Harmful.

Arch Intern Med. 2010 Nov 8.

Rosansky SJ, Eggers P, Jackson K, Glassock R, Clark WF.
Wm. Jennings Bryan Dorn Veterans Hospital, Columbia, South Carolina (Drs Rosansky); Arnold School of Public Health, University of South Carolina, Columbia (Dr Rosansky and Mr Jackson); National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland (Dr Eggers); Geffen School of Medicine at University of California, Los Angeles (Dr Glassock); and Division of Nephrology, London Health Sciences Centre, London, Ontario, Canada (Dr Clark).

Effect of erythropoietin levels on mortality in old age: the Leiden 85-plus Study

Published online ahead of print October 25, 2010
CMAJ 10.1503/cmaj.100347

Poor Social Support Increases Risk of Early Death, Worse Quality of Life

Washington, DC (October 18, 2010) — Dialysis patients with little social support from
friends and family are more likely to ignore doctors’ orders, experience a poorer quality
of life, and die prematurely, according to a study appearing in an upcoming issue of the
Clinical Journal of the American Society Nephrology (CJASN). The results suggest strong
social networks are important for maintaining dialysis patients’ health.

Higher serum bicarbonate levels within the normal range are associated with better survival and renal outcomes in African Americans.

Kidney Int. 2010 Oct 20.

Raphael KL, Wei G, Baird BC, Greene T, Beddhu S.
[1] VA Healthcare System, Salt Lake City, Utah, USA [2] Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.

Updated comorbidity assessments and outcomes in prevalent hemodialysis patients.

Hemodial Int. 2010 Oct;14(4):478-85.
doi: 10.1111/j.1542-4758.2010.00468.x.

Chang TI, Paik J, Greene T, Miskulin DC, Chertow GM.
Divisions of Nephrology General Internal Medicine, Stanford University School of Medicine, Palo Alto, California, USA Research Service, Veterans Affairs Salt Lake City Healthcare System, Salt Lake City, Utah, USA Division of Epidemiology, University of Utah, Salt Lake City, Utah, USA Tufts-New England Medical Center, Division of Nephrology, Boston, Massachusetts, USA.

FLEXING THEIR MUSCLES HELPS KIDNEY DISEASE PATIENTS LIVE LONGER

Patients with Large Upper Arm Muscles Gain Improved Health and Survival 

Washington, DC (October 8, 2010) — Kidney disease patients are healthier and live
longer if they’ve beefed up their muscles, according to a study appearing in an
upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN). The results suggest that patients may benefit from pumping iron or taking medications to boost their lean body mass.

An association between depressive symptoms and survival in incident dialysis patients.

Nephrol Dial Transplant. 2010 Oct 4.

Chilcot J, Davenport A, Wellsted D, Firth J, Farrington K.
1Renal Unit Lister Hospital, Stevenage, UK.

Does timing of dialysis in patients with ESRD and acute myocardial infarcts affect morbidity or mortality?

Clin J Am Soc Nephrol. 2009 Aug;4(8):1324-30.

Coritsidis G, Sutariya D, Stern A, Gupta G, Carvounis C, Arora R, Balmir S, Acharya A.

Mortality Studies in Dialysis Hemodialysis and Peritoneal Dialysis Patients Updated 1/27/2013

Dialysis Practices That Distinguish Facilities with Below-versus Above-Expected Mortality.

Clin J Am Soc Nephrol. 2010 Sep 28.

Spiegel B, Bolus R, Desai AA, Zagar P, Parker T, Moran J, Solomon MD, Khawar O, Gitlin M, Talley J, Nissenson A.
VA Greater Los Angeles Healthcare System, Los Angeles, California

Survival predictability of lean and fat mass in men and women undergoing maintenance hemodialysis.

OBJECTIVE: We examined the hypothesis that higher FM and LBM are associated with greater survival in MHD patents irrespective of sex.

Am J Clin Nutr. 2010 Sep 15.

Unintentional Weight Loss Is an Independent Predictor of Mortality in a Hemodialysis Population.

J Ren Nutr. 2010 Sep 10

Campbell KL, Maclaughlin HL.
Nutritional Sciences Division, King's College, London, United Kingdom; Department of Nutrition and Dietetics, King's College Hospital, London, United Kingdom.

Tachycardia as a predictor of poor survival in chronic haemodialysis patients.

Nephrol Dial Transplant. 2010 Sep 3

Iseki K,et al.
Dialysis Unit, University Hospital of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan.

Association of Cumulatively Low or High Serum Calcium Levels with Mortality in Long-Term Hemodialysis Patients.

Am J Nephrol. 2010 Sep 3;32(5):403-413.

Miller JE, Kovesdy CP, Norris KC, Mehrotra R, Nissenson AR, Kopple JD, Kalantar-Zadeh K.
Harold Simmons Center for Kidney Disease Research and Epidemiology,Torrance, Calif

Cognitive Impairment and 7-Year Mortality in Dialysis Patients.

Griva K, Stygall J, Hankins M, Davenport A, Harrison M, Newman SP.

Am J Kidney Dis. 2010 Aug 25.
Department of Psychology, National University of Singapore, Singapore; Unit of Behavioural Medicine, University College London and Health Services Research Group, City University London, London, UK.

Hemoglobin Variability and Mortality: Confounding by Disease Severity.

Am J Kidney Dis. 2010 Aug 27.

Weinhandl ED, Peng Y, Gilbertson DT, Bradbury BD, Collins AJ.
Chronic Disease Research Group, Minneapolis Medical Research Foundation, Minneapolis, MN.

Acute kidney injury network classification predicts in-hospital and long-term mortality in patients undergoing elective coronary artery bypass grafting surgery.

Eur J Cardiothorac Surg. 2010 Aug 23.

Li SY, et al
Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital and School of Medicine, National Yang-Ming University, Taipei, Taiwan

Homoarginine, Cardiovascular Risk, and Mortality.

März W, Meinitzer A, et al

Circulation. 2010 Aug 23.

Hemoglobin Variability Does Not Predict Mortality in European Hemodialysis Patients
online at http://jasn.asnjournals.org/ on
August 26, 2010, doi 10.1681/ASN.2009101017.

C-Reactive Protein and Mortality in Hemodialysis Patients: The Dialysis Outcomes and Practice Patterns Study (DOPPS).

Nephron Clin Pract. 2010 Aug 14;117(2):c167-c178.

Kawaguchi T, Tong L, Robinson BM, Sen A, Fukuhara S, Kurokawa K, Canaud B, Lameire N, Port FK, Pisoni RL.
Department of Epidemiology and Healthcare Research, Kyoto University, Graduate School of Medicine and Public Health, Kyoto, Japan.

What is causing the mortality in treating the anemia of chronic kidney disease: erythropoietin dose or hemoglobin level?

Curr Opin Nephrol Hypertens. 2010 Aug 4.

Singh AK.
Renal Division, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Serum Phosphate and Mortality in Patients with Chronic Kidney Disease.

Clin J Am Soc Nephrol. 2010 Aug 5.
Eddington H, et al
Salford Royal NHS Foundation Trust, Salford, United Kingdom; and.

Low Health Literacy Associates with Increased Mortality in ESRD.

J Am Soc Nephrol. 2010 Jul 29.
Cavanaugh KL, et al

Endogenous Testosterone and Mortality in Male Hemodialysis Patients: Is It the Result of Aging?

Clin J Am Soc Nephrol. 2010 Jul 22.
Gungor O, et al
Ege University School of Medicine, Izmir, Turkey

Rate of ESRD Exceeds Mortality among African Americans with Hypertensive Nephrosclerosis

Tahira P. Alves, et al for the AASK Collaborative Research Group
Journal of the American Society of Nephrology
Volume 21, Issue 7, July 2010
doi: 10.1681/ASN.2009060654

Effect of electronic patient record use on mortality in End Stage Renal Disease, a model chronic disease: retrospective analysis of 9 years of prospectively collected data.

BMC Med Inform Decis Mak. 2007 Nov 28;7:38.
Pollak VE, Lorch JA.
MIQS Inc,, 2100 Central Avenue, Suite 201, Boulder, Colorado 80301, USA

Outcome of Hemodialysis Patients Who Had Failed Peritoneal Dialysis.

Nephron Clin Pract. 2010 Jul 16;116(4):c300-c306.
Szeto CC, et al
Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, SAR, China.

Outcome of Acute Kidney Injury with Different Treatment Options: Long-Term Follow-up.
Clin J Am Soc Nephrol. 2010 Jul 15

Van Berendoncks AM, Elseviers MM, Lins RL; for the SHARF Study Group.
University of Antwerp, Antwerp, Belgium;

Serum alkaline phosphatase and mortality in hemodialysis patients.

Clin Nephrol. 2010 Aug;74(2):91-6.
Beddhu S, et al

A Randomized, Controlled Trial of Early versus Late Initiation of Dialysis
Published at www.nejm.org June 27, 2010 (10.1056/NEJMoa1000552)
Bruce A. Cooper, M.B., B.S., Ph.D. et al

Digoxin Associates with Mortality in ESRD (End Stage Renal Failure)

Kevin E. Chan, J. Michael Lazarus, and Raymond M. Hakim
J. Am. Soc. Nephrol., first published on June 24, 2010 as doi: doi:10.1681/ASN.2009101047

 

 

 

 


 
 
 
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