Hemodialysis.com discusses Nephrogenic Systemic Sclerosis - NSF-
in patients with chronic kidney disease or on dialysis.
Nephrogenic Systemic Sclerosis is a disorder of the skin, connective tissue and sometimes other organs. NSF has been recognized only in the past few years. Patients with NSF develop skin symptoms of discoloration followed by thickening or hardening of the skin and deeper tissues. The hardening, called fibrosis, may extend over joints and affect muscles, limited mobility. Patients may also experience pain or other symptoms in the skin and joints.
Nephrogenic Systemic Sclerosis has been associated with chronic kidney disease or kidney failure. In particular, Nephrogenic Systemic Sclerosis is now thought to likely be a new form of delayed reaction to a dye, called gadolinium. Gadolinium is used in MRI and MRA imaging tests to enhance the effectiveness of the radiology exams.
Recent dermatology studies appear to be able to detect gadolinium in the skin of patients with
Nephrogenic Systemic Sclerosis. Perhaps patients with chronic kidney disease were not able to effectively remove gadolinium after it was used as a contrast dye agent for MRI studies.
Other names for gadolinium include gadodiamide, GD-based contrast agents (GBCAs), Omniscan.
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WAYNE, N.J., March 14, 2011 /PRNewswire/ -- Bayer HealthCare Pharmaceuticals Inc. announced today that the U.S. Food and Drug Administration has approved Gadavist™ (gadobutrol) Injection, a macrocyclic gadolinium-based contrast agent (GBCA), for intravenous use in diagnostic magnetic resonance imaging (MRI) in adults and children (2 years of age and older) to detect and visualize areas with disrupted blood brain barrier (BBB) and/or abnormal vascularity of the central nervous system (CNS).
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FDA NEWS RELEASE September 9, 2010
Media Inquiries:
Karen Riley, 301-796-4674; karen.riley@fda.hhs.gov
Consumer Inquiries: 888-INFO-FDA
Enhanced screening recommended to detect kidney dysfunction
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Journal of the American Academy of Dermatology
Volume 63, Issue 3, Pages 389-399 (September 2010)
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