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Author Interviews


Author Interview: Dr. Bo Hu, PhD

Department of Quantitative Health Sciences
Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH


Kidney Function Can Improve in Patients with Hypertensive CKD

Bo Hu, Crystal Gadegbeku, Michael S. Lipkowitz, Stephen Rostand, Julia Lewis,
Jackson T. Wright, Lawrence J. Appel, Tom Greene, Jennifer Gassman, Brad C. Astor, and for the African-American Study of Kidney Disease and Hypertension Group
JASN Mar 8, 2012 ASN.2011050456;
 published ahead of print March 8, 2012,doi:10.1681/ASN.2011050456

What are the main findings of the study?

This robust analysis of long-term follow-up, a mean of 11 years, of patients in the AASK study provides strong evidence for the first time that kidney function can improve in some CKD patients (3% of the study cohort) over an extended period of time.

Were any of the findings unexpected?

Chronic kidney disease (CKD) is often assumed to be an unstoppable and progressive disease.

The end result of this progressive decline in kidney function is kidney failure, requiring chronic dialysis or a kidney transplant. 

What should clinicians and patients take away from this study?

There is wide variability in the rate of progression of CKD.

Our study documents with strong evidence that kidney function can improve in some patients with hypertensive CKD.

This finding, however, must be interpreted as exploratory and deserves further validation.

What recommendations do you have for future studies as a result of your study?

It is also highly deserved to examine factors that are associated with CKD improvement, which may uncover novel therapeutic or prevention strategies. 

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