Bidirectional relationship between chronic kidney and periodontal disease: a study using structural equation modeling
Kidney International advance online publication 6 October 2010; doi: 10.1038/ki.2010.384
Monica A Fisher, George W Taylor, Brady T West and Ellen T McCarthy
Department of Preventive Medicine and Public Health, University of Kansas School of Medicine, Wichita, Kansas, USA et al
A bidirectional relationship between CKD and periodontal disease is plausible, though this relationship has not been previously reported.
In this study, we assessed the potential for connections between CKD and periodontal disease, and mediators of these relationships using structural equation models of data from 11,211 adults  18 years of age who participated in the Third National Health and Nutrition Examination Survey.
Multivariable logistic regression models were used to test the hypothesis that periodontal disease was independently associated with CKD. Given the potential that the periodontal disease and CKD relationship may be bidirectional, a two-step analytic approach was used that involved tests for mediation and structural equation models to examine more complex direct and indirect effects of periodontal disease on CKD, and vice versa.
In two separate models, periodontal disease (adjusted odds ratio of 1.62), edentulism (adjusted odds ratio of 1.83), and the periodontal disease score were associated with CKD when simultaneously adjusting for 14 other factors.
Altogether, three of four structural equation models support the hypothesized relationship. Thus, our analyses support a bidirectional relationship between CKD and periodontal disease, mediated by hypertension and the duration of diabetes.
Renal Failure
Posted online on January 9, 2012. (doi:10.3109/0886022X.2011.643351)
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Dirk Ziebolz, Petra Fischer, Else Hornecker, Rainer F. Mausberg
Article first published online: 9 SEP 2011
DOI: 10.1111/j.1542-4758.2011.00606.x
2011 International Society for Hemodialysis
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Bastos JA, Diniz CG, Bastos MG, Vilela EM, Silva VL, Chaoubah A, Souza-Costa DC, Andrade LC.
Postgraduate Program in Health - Concentration Area, Brazilian Health, Federal University of Juiz de Fora, MG, Brazil.
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